Zilberman Y, Cohen B, Becker A Familial trends in palatal canines, anomalous lateral incisors and related phenomena. Eur J Orthod. 1990; 12:135-139
Robertsson S, Mohlin B The congenitally missing upper lateral incisor. A retrospective study of orthodontic space closure versus restorative treatment. Eur J Orthod. 2000; 22:697-710
Locht S Panoramic radiographic examination of 704 Danish children aged 9-10 years. Comm Dent Oral Epidemiol. 1980; 8:375-380
Brook AH Dental anomalies of number, form and size: their prevalence in British schoolchildren. J Int Assoc Dent Child. 1974; 5:37-53
Lervik T, Cowley GC Observations of dental disease and anomalies in 9 to 11-year-old Norwegian children. Acta Odontol Scand. 1983; 41:45-51
Hunstadbraten K Hypodontia in the permanent dentition. ASDC J Dent Child. 1973; 40:115-117
Bergström K An orthopantomographic study of hypodontia, supernumeraries and other anomalies in schoolchildren between the ages of 8-9 years. An epidemiological study. Swed Dent J. 1977; 1:145-157
Larmour CJ, Mossey P, Bikram ST, Forgie AH, Stirrups DR Hypodontia - a retrospective review of prevalence and etiology Part 1. Quintessence Int. 2005; 36:263-270
Stamatiou J, Symons AL Agenesis of the permanent lateral incisor: distribution, number and sites. J Clin Ped Dent. 1991; 15:244-246
Arte S, Nieminen P, Pirinen S, Thesleff I, Peltonen L Gene defect in hypodontia: exclusion of EGF, EGFR and FGR-3 as candidate genes. J Dent Res. 1996; 75:1346-1352
Louw JD, Smith BJ, McDonald F, Palmer RM The management of developmentally absent maxillary lateral incisors - a survey of orthodontists in the UK. Br Dent J. 2007; 23
Lai PY, Seow WK A controlled study of the association of various dental anomalies with hypodontia of permanent teeth. Pediatr Dent. 1989; 11:291-296
Brin I, Becker A, Shalhav M Position of the maxillary permanent canine in relation to anomalous or missing lateral incisors: a population study. Eur J Orthod. 1986; 8:12-16
Becker A, Smith P, Behar R The incidence of anomalous maxillary lateral incisors in relation to palatally displaced cuspids. Angle Orthod. 1981; 51:24-29
Hobkirk JA, Goodman JR, Jones SP Presenting complaints and findings in a group of patients attending a hypodontia clinic. Br Dent J. 1994; 177:337-339
Shaw WC, Addy M, Ray C Dental and social effects of malocclusion and effectiveness of orthodontic treatment: a review. Comm Dent Oral Epidemiol. 1980; 8:36-45
Kinzer GA, Kokich VO Managing congenitally missing lateral incisors part 1: canine substitution. Adv Est Interdisc Dent. 2007; 3:2-5
Thilander B, Odman J, Gröteborg K, Friberg B Osseointegrated implants in adolescents. An alternative in replacing missing teeth?. Eur J Orthod. 1994; 16:84-95
Senty EL The maxillary cuspid and missing lateral incisors: esthetics and occlusion. Angle Orthod. 1976; 46:465-371
Sarver DM, Ackerman MB Dynamic smile visualization and quantification: Part 2. Smile analysis and treatment strategies. Am J Orthod Dentofacial Orthop. 2003; 124:116-127
Morgan C, Howe L The restorative management of hypodontia with implants: 2. Planning and treatment with implants. Dent Update. 2004; 31:22-30
Savarrio L, McIntyre GT To open or to close space - that is the missing lateral incisor question. Dent Update. 2005; 32:16-25
Lombardi RE The principles of visual perception and their clinical application to denture esthetics. J Prosthet Dent. 1973; 29:358-382
Zachrisson BU Improving orthodontic results in cases with maxillary incisors missing. Am J Orthod. 1978; 73:274-289
Thordarson A, Zachrisson BU, Mjör IA Remodelling of canines to the shape of lateral incisors by grinding: a long-term clinical and radiographic evaluation. Am J Orthod Dentofacial Orthop. 1991; 100:123-132
Pinho T, Maciel P, Pollmann C Developmental disturbances associated with agenesis of the permanent maxillary lateral incisor. Br Dent J. 2009; 207
Gahan MJ, Lewis BRK, Moore D, Hodge TM The orthodontic-restorative interface: 1. Patient assessment. Dent Update. 2010; 37:74-80
These two articles aim to outline the assessment and explain the treatment options for those patients who present with missing upper lateral incisors. In Part 1, emphasis is placed on the diagnosis and need for a combined orthodontic-restorative approach to provide optimal patient care.
Clinical Relevance: The management of patients with absence of one or both lateral incisors can be an aesthetic and functional challenge. Frequently, a number of different factors need to be considered in order to achieve the best end result. We suggest that a combined orthodontic-restorative approach be considered at the start of the planning process, in order to consider all treatment possibilities.
Article
The developmental absence of teeth (hypodontia) is not an uncommon finding amongst orthodontic patients and maxillary incisors are amongst the most commonly found to be absent, with a reported incidence of 1–2% in Caucasians,1 accounting for approximately 20% of all absent permanent teeth.2,3 The background incidence of hypodontia of secondary teeth in North-Western Europe is between 3.5 and 10%.4,5,6,7 It is more common in females.8
The lateral incisors may be unilaterally or bilaterally absent, with bilateral agenesis more common than unilateral agenesis.9 The absence of maxillary lateral incisors generally follows an autosomal dominant mode of inheritance with incomplete penetrance.10 Its absence can also be associated with conditions such as ectodermal dysplasia, cleft lip and palate, Down's syndrome, Incontinentia pigmenti and following early irradiation of tooth germs.11
Problems associated with missing lateral incisors
The patient's, or parents', concern will often relate to the dental aesthetics, for example spacing, rotations and centreline deviation (Figures 1 and 2). They may comment on the canines which are more prominent, with the patient being unaware of a missing incisor tooth. An asymmetrical smile may also be of concern, specifically in the case of an absent single maxillary lateral incisor. This is a frequent finding as the contralateral incisors are commonly diminutive and peg-shaped.12
Additionally, some have demonstrated a link between the absence of maxillary lateral incisors and ectopic permanent canines13,14 (Figure 3). This may represent a dental health risk, should the canine impaction lead to pathological cystic change or root resorption of the adjacent teeth.
From a psycho-social standpoint, the absence of upper lateral incisors may affect how a child is perceived by his/her peers. This particular dental anomaly has been associated with a perceived aggressive attitude and may be associated with negative social experiences.15,16
Functional problems need to be assessed in both static and dynamic occlusion. When assessing the static occlusion, attention should be paid to the inter-occlusal space in the lateral incisor region. This may be reduced due to the over-eruption of the opposing canine tooth (Figure 4). Replacement of the lateral incisor might then be compromised in the absence of orthodontic bite opening prior to restoration of the space. Assessing the dynamic occlusion will determine the existence of canine guidance and whether it could be retained.
Patient factors
At the back of the clinician's mind there needs to be an awareness of the patient's present and potential future access and attitude to specialist and general dentistry. In many ways this is the starting point of any treatment planning process.
A good rule of thumb is that the treatment of choice should be the least invasive that satisfies the expected aesthetics and functional needs of the patient.17 Outlined below are other factors that should be considered in the planning process.
Patient preference
It should be borne in mind that patients may choose one option over another for psychosocial or financial reasons. To some the thought of ‘false teeth’ is unacceptable whereas others are driven by the best aesthetic result, whatever that involves. The financial considerations are variable and depend on the individual and local NHS funding. The maintenance of any restorative treatment will involve a cost implication. Planning ahead for implant funding on the NHS is not possible for the majority of patients. Such ‘ring fencing’ is not available and application for funding is required once the patient reaches skeletal maturity.
Age
Consideration of the stage of skeletal and dental maturity is important when planning treatment, especially when considering restorative replacement of the missing teeth with dental implants. Optimum timing for placing implants is when the facial growth is complete, as placement of implants prior to completion of facial growth will lead to infraocclusion of the implant relative to the adjacent teeth.18 Young patients and their families need to be aware of this at the start of treatment as intermediate restorations, such as resin-retained bridges or partial acrylic dentures, will be required on completion of the orthodontic treatment.
Para-functional activity
Habits such as nail-biting, grinding/clenching can adversely affect the success of restorative treatments, particularly implant-retained crowns and resin-retained bridgework.19
Clinical examination
Skeletal relationship
In the first instance, the skeletal relationship needs to be assessed as this would influence the treatment approach, in particular the decision as to whether the space associated with a missing lateral incisor is to be closed or opened/re-distributed for a prosthetic replacement.2 For example, a patient with a mild skeletal III pattern may be better served with space opening and bringing the upper incisor teeth forward, as opposed to space closure at the risk of further retracting the upper labial segment.
Soft tissues
The amount of gingival tissue exposure when the lips are at rest and on smiling should be assessed. When camouflaging the missing incisor with space closure the emergence profile of the canine might differ from the contralateral tooth or be out of balance with the central incisor teeth. A canine with a narrow mesiodistal width at the CEJ will produce a more aesthetic emergence profile.20 With a high lip line this would be more obvious, however, with a lower lip line the soft tissue curtain would cover the gingival margins and so hide this discrepancy (Figures 5 and 6). The same thought pattern exists with the heights of the gingival margins.
Classically, the gingival margins of the central incisors and the canines should ideally be level with each other and the gingival margin of the lateral incisors should be slightly lower.21 The importance of achieving this is again influenced by the amount of exposure of these gingival margins, and so on the resting lip line and smile line. Finally, in patients with a high smile line the prominence of the canine root may also cause aesthetic concerns.20
Prior to treatment planning, a detailed assessment of the periodontal structures, including plaque control, is required. The existing teeth are evaluated for caries, restorations, colour and shape. The quality and the amount of hard and soft tissue in the edentulous spaces should also be taken into consideration.19 Poor cervical margin appearance can be a problem if there is no bone in the desired position.22 Lack of labio-lingual width of alveolar bone will compromise future prosthetic tooth replacement. If insufficient ridge width exists, a bone graft may become necessary.
Type of malocclusion
To a certain degree the malocclusion may dictate the final treatment plan. For example, in the case of a patient with a well aligned lower arch and a full unit Class II molar relationship, if it were acceptable to close the spaces fully and align the canines (with or without later adjustment) next to the central incisors, this would be the treatment of choice. To open the spaces for prosthetic lateral incisors would require distalization of the upper buccal segment or extraction of a premolar unit. This treatment plan may also be suitable for Class I patients with lower arch crowding which would benefit from lower arch extractions23 (Figure 7).
As indicated above, in a mild Class III case where dento-alveolar compensation is planned, space opening may be the most appropriate option as the mechanics of space opening would help to create a Class I incisor relationship, which would be stable if the overbite was adequate. Space closure would worsen a Class III incisor relationship (Figure 8). In orthognathic cases, space closure in Class III cases and space opening in Class II cases may be appropriate treatment plans as the surgical movements will overcome any changes in the incisor relationship.
Canines: size, shape and colour
The aim of the combined orthodontic-restorative approach is to create an aesthetic arrangement of teeth that have a colour, size and morphology which are within normal limits.19 This requires the anterior teeth to be in a harmonious relationship. The permanent lateral incisor crown is usually 5.5–6.7 mm wide and is in ‘golden proportion’ to the width of the permanent central incisor and canine. The ‘golden proportion’ implies a ratio of 1:1.618 in the arrangement of the maxillary teeth from a frontal view, but its strict use in clinical dentistry is limited,24 though its importance should not be overlooked. An ideal canine would be one where its dimensions are similar to that of the missing unit (Figures 9 and 10). A pointed canine can be trimmed and it is possible to restore the mesio-incisal and disto-incisal edges of the canine to recreate normal lateral contours.25 A slightly wider canine can be reduced and masked but a bulky and broad tooth would not be in harmony with the surrounding dentition (Figures 11 and 12). It is important to avoid over reduction as the underlying dentine will show through the thin enamel.26 Any dentine exposure will require restorative intervention.
It is not unusual for the canines to be darker than the central incisors. The colour discrepancy between the central incisor and the canine has been reported to be the primary cause of dissatisfaction in people who have completed a space-closure treatment plan.2 Restorative options to address this may include bleaching (less invasive) or veneering (more invasive) of the canine. Finally, as mentioned above, consideration to the width of the canine crown at the cemento-enamel junction (CEJ) should be made. This could be evaluated radiographically.
Tooth size discrepancies
It is thought that microdontia is a variable expression of the same developmental disturbance that causes tooth agenesis.27 Therefore, it is not uncommon to find cases where one lateral incisor is absent whilst the contralateral tooth is present but diminutive and peg-shaped. Depending on other factors, it may be best to build up the smaller tooth or extract the peg-shaped lateral incisor rather than the restorative build-up to create symmetry.
Tooth size-arch length discrepancy
The need to create space for the missing tooth must be balanced with the space available. Space closure in spaced arches with well intercuspated occlusion may be a difficult and lengthy process. In such cases, it may be easier and quicker to redistribute the space for the restorative replacement of the missing tooth/teeth. In crowded upper arches, where already there has been some space loss, further space closure may be preferable, as often a premolar tooth would have to be extracted to provide adequate space for the replacement of the missing tooth. This is at times considered an excessive biological cost for a modest functional and aesthetic gain.20 However, if space closure causes a poor aesthetic central incisor-permanent canine relationship, the patient may prefer re-creation of space for the replacement of the missing tooth. Clearly, the need for the patient to understand the long-term implications of this decision fully is paramount.
Radiographic examination
The suspected absence of the permanent lateral incisor should be confirmed radiographically if the tooth has failed to erupt by the age of 9 years or within 6 months of the contralateral tooth. There are a number of different radiographs which may aid the treatment planning process. The simplest is a peri-apical image, though the dental panoramic radiograph is the most commonly used. With this image it should be remembered that a tooth may be outside of the focal trough and so appear ‘absent’.
Diagnostic set-up
A diagnostic set-up is a very useful tool to evaluate the orthodontic tooth movements and the nature of the restorative input, as well the suitability of a particular treatment plan.
It also helps to decide between a number of treatment options, as well as acting as a visual aid to the patient.28 A diagnostic set-up may simply involve the intra-oral addition of either white orthodontic wax or composite resin to unetched tooth surfaces at the chairside.
This is especially useful in cases where a build-up of the existing teeth is indicated rather than space opening.
A traditional wax-up, or Kesling set-up, involves the repositioning of the teeth to mimic the orthodontic tooth movements, as well as replacement of the missing teeth and reshaping others, if indicated (Figure 13). It is possible to undertake a facebow recording and mount the wax-ups on an adjustable articulator to replicate the dynamic occlusion.28
Conclusion
In order to address the aesthetics and functional concerns of patients with missing upper lateral incisors, detailed and thorough clinical and radiographic examinations are required. In addition, diagnostic aids such as Kesling set-ups may prove to be very useful in planning the treatment as a visual aid for patients.