Suri L, Gagari E Delayed tooth eruption: pathogenesis, diagnosis, and treatment. A literature review. Am J Orthod Dentofacial Orthop. 2004; 124:432-445
Nolla CM The development of the human dentition. ASDC J Dent Child. 1960; 27:254-266
O'Connell AC, Puck JM, Grimbacher B Delayed eruption of permanent teeth in hyperimmunoglobulinemia E recurrent infection syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000; 89:177-185
Moretti de Lima A, Arantes Sperandio V, Pereira da Rocha S Do you know this syndrome?. An Bras Dermatol. 2013; 88:836-838
Grimbacher B, Holland SM, Puck JM Hyper-IgE syndromes. Immunol Rev. 2005; 203:244-250
Kamasaki Y, Hidaka K, Nishiguchi M, Fujiwara T Dental manifestations of a pediatric patient with hyperimmunoglobulin E syndrome: a case report. J Dent Child. 2012; 79:100-104
Holland SM, DeLeo FR, Elloumi HZ STAT3 Mutations in the hyper-IgE syndrome. N Engl J Med. 2007; 357:1608-1619
Laurent J, Noirot C, Ansquer JC How to define the normal level of serum IgE in adults?. Ann Med Interne (Paris). 1985; 136:419-422
Grimbacher B, Holland SM, Gallin JI Hyper-IgE syndrome with recurrent infections – an autosomal dominant multisystem disorder. N Engl J Med. 1999; 340:692-702
Freeman AF, Holland SM Clinical manifestations, etiology, and pathogenesis of the hyper-IgE syndromes. Pediatr Res. 2008; 65:32R-37R
Cohen-Solal M, Prieur AM, Prin L Cytokine-mediated bone resorption in patients with the hyperimmunoglobulin E syndrome. Clin Immunol Immunopathol. 1995; 76:75-81
Welbury R, 4th edn. New York: Oxford University Press; 2001
Frank CA Treatment options for impacted teeth. J Am Dent Assoc. 2000; 135:623-632
Becker A, Lustmann J, Shteyer A Cleidocranial dysplasia: Part 1 – General principles of the orthodontic and surgical treatment modality. Am J Orthod Dentofacial Orthop. 1997; 111:28-33
Doruk C, Bicakci AA, Babacan H Orthodontic and orthopedic treatment of a patient with incontinentia pigmenti. Angle Orthod. 2003; 73:763-788
Tsuchiya Y, Sueishi K, Yatabe K, Yamaguchi H A case of Antley-Bixler syndrome with severe skeletal Cl. III malocclusion. Bull Tokyo Dent Coll. 2003; 45:87-93
Orthodontic management of delayed permanent tooth eruption and a case report of hyper-IgE syndrome Nabeel Bhatti Pratik K Sharma Dental Update 2024 10:1, 707-709.
Authors
NabeelBhatti
BDS MBBS, MFDS MRCS
StR Oral and Maxillofacial Surgery, Oral and Maxillofacial Department, The Royal London Hospital E1 1BB
Senior Clinical Lecturer and Consultant Orthodontist, Department of Orthodontics, Centre for Oral Growth and Development, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, E1 4NS, UK
This article aims to look at the treatment and management of patients presenting with delayed tooth eruption of the permanent dentition. We describe the case of a 17-year-old girl who presented having been diagnosed with Hyper-IgE syndrome. The patient was positive for the STAT-3 gene and presented with a history of some classic Hyper-IgE features. There was a history of multiple skin abscesses and she was on long-term antibiotics. She presented in the mixed dentition with multiple retained deciduous teeth and a full complement of unerupted and fully formed permanent teeth. This article will describe features of this syndrome and discuss management strategies for patients presenting with delayed eruption.
Clinical Relevance: This case study highlights the difficulties in managing patients who present with retained primary dentition at an older age. It also presents a rare case presentation of a patient with Hyper-IgE.
Article
Delayed tooth eruption (DTE) is a term described as the ‘emergence of a tooth into the oral cavity at a time that deviates significantly from norms established for different races, ethnicities, and sexes’.1 In general, the causes for delayed eruption are unknown but the literature does detail specific conditions (Table 1) that are often associated with it.2 The eruption of teeth is a sequential process and deviations from the normal sequence can be separated into genetic and environmental causes.3
There are two distinct processes which are involved in the eruption of permanent teeth. One is the intra-bony tooth formation process and the other is the eruption process itself. One study shows that the delay in establishment of the permanent dentition is not due to delay in primary teeth eruption nor delay in permanent tooth development. Instead, it suggests that the presence of the primary dentition due to failure of exfoliation may be the contributing factor.4
Register now to continue reading
Thank you for visiting Orthodontic Update and reading some of our resources. To read more, please register today. You’ll enjoy the following great benefits:
